Clinical Trials

Clinical trials are currently underway in the UK and around the world to explore new drugs capable of treating MND.

A clinical trial is a scientifically controlled study of the safety and effectiveness of a therapeutic agent (such as a drug) using consenting people.

There are different types of clinical trials but the randomized clinical trial (RCT) is the most commonplace. In an RCT, the effects of the experimental treatment will be compared between the groups who receive the treatment and the group who receive no treatment (the control, or placebo group). It is important to remember, therefore, that if you are asked, or volunteer, to participate in a trial, you may not be allocated to the treatment group : instead, you may be allocated to the control group.

To date, Riluzole is still the only proven treatment for MND. However, research into finding a successful treatment for MND is on-going. Details of some clinical trials (for new drugs) which are taking place in the United Kingdom at present, are listed below.



Motor Neurone Disease -Systematic multi-arm Adaptive Randomisation Trial (MND-SMART) is a landmark drug trial designed to speed up the time it takes to find medicines that can slow, stop, or reverse the progression of Motor Neurone Disease.

The trial is being led by researchers at the Euan MacDonald Centre for MND Research at the University of Edinburgh and the trial will include as many people with MND as possible, regardless of how the disease or current treatments affect them. The initial trial centre is in Edinburgh, but plans to open centres across the UK are on-going. Identifier: NCT04302870


MIROCALS: Modifying Immune Response and OutComes in ALS (MIROCALS) Identifier: NCT03039673

Drug name: Interleukin 2 or IL-2

Sponsor: Centre Hospitalier Universitaire de Nīmes

Start Date June 19, 2017

Estimated Completion Date September 2021

United Kingdom - Recruiting Centres include

  • Glasgow Queen Elizabeth Hospital (Recruitment now closed)
  • Trafford Centre for Biomedical Research - Brighton, United Kingdom, BN1 9RY  
  • North-East London and Essex MND Regional Care Centre - London, United Kingdom, E1 4NS
  • King's MND Care and Research Centre - London, United Kingdom, SE5 8AF
  • Centre for Neuromuscular Diseases - National Hospital of Neurology - London, United Kingdom, WC1N 3BG
  • Sheffield Care and Research Centre - Sheffield, United Kingdom, S10 2JF


 Information on World-Wide Clinical Trials and Research can be found on the website below :

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